*Equal contribution † Corresponding author
Publications & Preprints
Rare coding mutations identify 36 large-effect risk genes in obsessive-compulsive disorder and chronic tic disorders
Wang B, Tran MT, Wang S, Liu Y, Olfson E, Wang G, Sun N, Dea J, Olwal CO, Bertolace L, Bloch MH, Cappi C, Chang YC, Chavira D, Coffey BJ, Falkenstein MJ, Frank AC, Franklin ME, Garayalde S, Garrido H, Grados M, Hatem R, Howell AL, Khim S, Kuckertz JM, Le MM, Libby A, McCarty RJ, McNamara ME, McNeil D, Miguel EC, Nasello C, Nguyen B, Norbu T, Oh L, Ordway A, Paciotti C, Peskin VA, Pittenger C, Simpson HB, Martin HS, Tischfield MA, Xing J, Zakrzewski JJ, Tourette International Collaborative Genetics (TIC Genetics), Dietrich A, Gilbert DL, Hoekstra PJ, Kim YS, Kuperman S, Rosen A, Zinner SH, Bouhaddou M, King RA, Rouleau G, Ressler KJ, Mathews CA, Krogan NJ, Sestan N, Tischfield JA†, Lee AM†, Heiman GA†, Fernandez TV†, Willsey AJ†, State MW†
bioRxiv (2025) PDF
Convergence of autism proteins at the cilium
Kostyanovskaya E, Lasser MC, Wang B, Schmidt J, Bader E, Buteo C, Arbelaez J, Sindledecker AR, McCluskey KE, Castillo O, Wang S, Dea J, Helde KA, Michael Graglia J, Brimble E, Kastner DB, Ehrlich AT, State MW, Jeremy Willsey A, Willsey HR
bioRxiv (2024) PDF
Oxytocin receptor controls promiscuity and development in prairie voles
Sharma R, Berendzen KM, Everitt A, Wang B, Williams G, Wang S, Quine K, Larios RD, Long KLP, Hoglen N, Sulaman BA, Heath MC, Sherman M, Klinkel R, Cai A, Galo D, Caamal LC, Goodwin NL, Beery A, Bales KL, Pollard KS, Willsey AJ, Manoli DS
bioRxiv (2024) PDF
Koolen-de Vries Syndrome causal gene KANSL1 is required for motile ciliogenesis
Schmidt JD, Terala A, McCluskey KE, Wang B, Pfalzer AC, Willsey HR
bioRxiv (2024) PDF
Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity
Kwon JJ, Dilly J, Liu S, Kim E, Bian Y, Dharmaiah S, Tran TH, Kapner KS, Ly SH, Yang X, Rabara D, Waybright TJ, Giacomelli AO, Hong AL, Misek S, Wang B, Ravi A, Doench JG, Beroukhim R, Lemke CT, Haigis KM, Esposito D, Root DE, Nissley DV, Stephen AG, McCormick F, Simanshu DK, Hahn WC, Aguirre AJ
bioRxiv (2024) PDF
A foundational atlas of autism protein interactions reveals molecular convergence
Wang B*, Vartak* R, Zaltsman Y*, Naing ZZC*, Hennick KM, Polacco BJ, Bashir A, Eckhardt M, Bouhaddou M, Xu J, Sun N, Lasser MC, Zhou Y, McKetney J, Guiley KZ, Chan U, Kaye JA, Chadha N, Cakir M, Gordon M, Khare P, Drake S, Drury V, Burke DF, Gonzalez S, Alkhairy S, Thomas R, Lam S, Morris M, Bader E, Seyler M, Baum T, Krasnoff R, Wang S, Pham P, Arbalaez J, Pratt D, Chag S, Mahmood N, Rolland T, Bourgeron T, Finkbeiner S, Swaney DL, Bandyopadhay S, Ideker T, Beltrao P, Willsey HR, Obernier K, Nowakowski TJ, Hüttenhain R, State MW, Willsey AJ, Krogan NJ
bioRxiv (2024) PDF
Autism genes converge on microtubule biology and RNA-binding proteins during excitatory neurogenesis
Sun N*, Teyssier N*, Wang B, Drake S, Seyler M, Zaltsman Y, Everitt A, Teerikorpi N, Willsey HR, Goodarzi H, Tian R, Kampmann M, Willsey AJ
bioRxiv (2024) PDF
Rare X-linked variants carry predominantly male risk in autism, Tourette syndrome, and ADHD
Wang S, Wang B, Drury V, Drake S, Sun N, Alkhairo H, Arbelaez J, Duhn C; Tourette International Collaborative Genetics (TIC Genetics); Bal VH, Langley K, Martin J, Hoekstra PJ, Dietrich A, Xing J, Heiman GA, Tischfield JA, Fernandez TV, Owen MJ, O'Donovan MC, Thapar A, State MW, Willsey AJ
Nature Communications (2023) PDF
Pleiotropy of autism-associated chromatin regulators
Lasser M, Sun N, Xu Y, Wang S, Drake S, Law K, Gonzalez S, Wang B, Drury V, Castillo O, Zaltsman Y, Dea J, Bader E, McCluskey KE, State MW, Willsey AJ, Willsey HR
Development (2023) PDF
Genomics, convergent neuroscience and progress in understanding autism spectrum disorder
Willsey HR, Willsey AJ, Wang B, State MW
Nature Reviews Neuroscience (2022) PDF
SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization
Dai C, Rennhack JP, Arnoff TE, Thaker M, Younger ST, Doench JG, Huang AY, Yang A, Aguirre AJ, Wang B, Mun E, O'Connell JT, Huang Y, Labella K, Talamas JA, Li J, Ilic N, Hwang J, Hong AL, Giacomelli AO, Gjoerup O, Root DE, Hahn WC
Cell Reports (2021) PDF
Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses
Lo JA, Kawakubo M, Juneja VR, Su MY, Erlich TH, LaFleur MW, Kemeny LV, Rashid M, Malehmir M, Rabi SA, Raghavan R, Allouche J, Kasumova G, Frederick DT, Pauken KE, Weng QY, Pereira da Silva M, Xu Y, van der Sande AAJ, Silkworth W, Roider E, Browne EP, Lieb DJ, Wang B, Garraway LA, Wu CJ, Flaherty KT, Brinckerhoff CE, Mullins DW, Adams DJ, Hacohen N, Hoang MP, Boland GM, Freeman GJ, Sharpe AH, Manstein D, Fisher DE
Science Translational Medicine (2021) PDF
Parallel in vivo analysis of large-effect autism genes implicates cortical neurogenesis and estrogen in risk and resilience
Willsey HR, Exner CRT, Xu Y, Everitt A, Sun N, Wang B, Dea J, Schmunk G, Zaltsman Y, Teerikorpi N, Kim A, Anderson AS, Shin D, Seyler M, Nowakowski TJ, Harland RM, Willsey AJ, State MW
Neuron (2021) PDF
Leveraging large genomic datasets to illuminate the pathobiology of autism spectrum disorders
Searles Quick VB*, Wang B*, State MW
Neuropsychopharmacology Reviews (2021) PDF
Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability
Paolella BR, Gibson WJ, Urbanski LM, Alberta JA, Zack TI, Bandopadhayay P, Nichols CA, Agarwalla PK, Brown MS, Lamothe R, Yu Y, Choi PS, Obeng EA, Heckl D, Wei G, Wang B, Tsherniak A, Vazquez F, Weir BA, Root DE, Cowley GS, Buhrlage SJ, Stiles CD, Ebert BL, Hahn WC, Reed R, Beroukhim R
Elife (2017) PDF
ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition
Wang B*, Krall EB*, Aguirre AJ*, Kim M, Widlund HR, Doshi MB, Sicinska E, Sulahian R, Goodale A, Cowley GS, Piccioni F, Doench JG, Root DE, Hahn WC
Cell Reports (2017) PDF
KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer
Krall EB*, Wang B*, Munoz DM*, Ilic N, Raghavan S, Niederst MJ, Yu K, Ruddy DA, Aguirre AJ, Kim JW, Redig AJ, Gainor JF, Williams JA, Asara JM, Doench JG, Janne PA, Shaw AT, McDonald Iii RE, Engelman JA, Stegmeier F, Schlabach MR, Hahn WC
Elife (2017) PDF
Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners
Schulman S, Wang B, Li W, Rapoport TA
Proceedings of the National Academy of Sciences (2010) PDF